Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

• Main Authors: Allison Zarkin (Author), Rajwana Jahan (Author), Rajendra Uprety (Author), Yanan Zhang (Author), Charles McElhinny (Author), Rodney Snyder (Author), Elaine Gay (Author), Gabriel Jewula (Author), Heather Bool (Author), Stewart D Clark (Author), Scott Runyon (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of the neuropeptide S receptor (NPSR) system has been shown to produce anxiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse and duration of anesthetics. We report here the discovery of a no...