Adenosine Generated in the Bone Marrow Niche Through a CD38-Mediated Pathway Correlates With Progression of Human Myeloma

• Main Authors: Alberto L Horenstein (Author), Valeria Quarona (Author), Denise Toscani (Author), Federica Costa (Author), Antonella Chillemi (Author), Vito Pistoia (Author), Nicola Giuliani (Author), Fabio Malavasi (Author)
• Format: Book
• Published: BMC, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Human myeloma cells express CD38 at high levels and grow in hypoxic niches inside the bone marrow. Myeloma cells respond to hypoxia with metabolic changes leading to aerobic glycolysis, thus reducing adenosine triphosphate (ATP) and increasing NAD+. Our hypothesis is that these conditions f...