Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties

• Egile Nagusiak: Kseniya Kovaleva (Egilea), Olga Yarovaya (Egilea), Konstantin Ponomarev (Egilea), Sergey Cheresiz (Egilea), Amirhossein Azimirad (Egilea), Irina Chernyshova (Egilea), Alexandra Zakharenko (Egilea), Vasily Konev (Egilea), Tatiana Khlebnikova (Egilea), Evgenii Mozhaytsev (Egilea), Evgenii Suslov (Egilea), Dmitry Nilov (Egilea), Vytas Švedas (Egilea), Andrey Pokrovsky (Egilea), Olga Lavrik (Egilea), Nariman Salakhutdinov (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In this paper, a series of novel abietyl and dehydroabietyl ureas, thioureas, amides, and thioamides bearing adamantane moieties were designed, synthesized, and evaluated for their inhibitory activities against tyrosil-DNA-phosphodiesterase 1 (TDP1). The synthesized compounds were able to inhibit TD...