Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties

• Главные авторы: Kseniya Kovaleva (Автор), Olga Yarovaya (Автор), Konstantin Ponomarev (Автор), Sergey Cheresiz (Автор), Amirhossein Azimirad (Автор), Irina Chernyshova (Автор), Alexandra Zakharenko (Автор), Vasily Konev (Автор), Tatiana Khlebnikova (Автор), Evgenii Mozhaytsev (Автор), Evgenii Suslov (Автор), Dmitry Nilov (Автор), Vytas Švedas (Автор), Andrey Pokrovsky (Автор), Olga Lavrik (Автор), Nariman Salakhutdinov (Автор)
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• Опубликовано: MDPI AG, 2021-05-01T00:00:00Z.
• Предметы: article
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In this paper, a series of novel abietyl and dehydroabietyl ureas, thioureas, amides, and thioamides bearing adamantane moieties were designed, synthesized, and evaluated for their inhibitory activities against tyrosil-DNA-phosphodiesterase 1 (TDP1). The synthesized compounds were able to inhibit TD...