Prediction of Oral Absorption of Low-Solubility Drugs by Using Rat Simulated Gastrointestinal Fluids: The Importance of Regional Differences in Membrane Permeability and Solubility

• मुख्य लेखकों: Yusuke Tanaka (लेखक), Toshiyuki Baba (लेखक), Koji Tagawa (लेखक), Ryoichi Waki (लेखक), Shunji Nagata (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2014-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Purpose. This study aimed to develop a novel approach for predicting the oral absorption of low-solubility drugs by considering regional differences in solubility and permeability within the gastrointestinal (GI) tract. Methods. Simulated GI fluids were prepared to reflect rat in vivo bile acid and...