HPV 16 E5 oncoprotein is expressed in early stage carcinogenesis and can be a target of immunotherapy

• Main Authors: Francesca Paolini (Author), Gianfranca Curzio (Author), Marcelo Nazario Cordeiro (Author), Silvia Massa (Author), Luciano Mariani (Author), Fulvia Pimpinelli (Author), Antonio Carlos de Freitas (Author), Rosella Franconi (Author), Aldo Venuti (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HPV16 persistent infection is a well-known condition that precedes human cancer development. High risk HPV E5 proteins cooperate with E6/E7 oncogenes to promote hyper-proliferation of infected cells leading to possible cancer progression. Thus, presence of E5 viral transcripts could be a key marker...