Enhanced Expression of Human Epididymis Protein 4 (HE4) Reflecting Pro-Inflammatory Status Is Regulated by CFTR in Cystic Fibrosis Bronchial Epithelial Cells

• Egile Nagusiak: Zsolt Bene (Egilea), Zsolt Fejes (Egilea), Tibor Gabor Szanto (Egilea), Ferenc Fenyvesi (Egilea), Judit Váradi (Egilea), Luka A. Clarke (Egilea), Gyorgy Panyi (Egilea), Milan Macek (Egilea), Margarida D. Amaral (Egilea), István Balogh (Egilea), Béla Nagy (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Decreased human epididymis protein 4 (HE4) plasma levels were reported in cystic fibrosis (CF) patients under CFTR potentiator ivacaftor therapy, which inversely correlated with lung function improvement. In this study, we investigated whether HE4 expression was affected via modulation of CFTR funct...