Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

• Asıl Yazarlar: Ze Wang (Yazar), Li Zhao (Yazar), Bo Zhang (Yazar), Jiahe Feng (Yazar), Yule Wang (Yazar), Bin Zhang (Yazar), Haixiao Jin (Yazar), Lijian Ding (Yazar), Ning Wang (Yazar), Shan He (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Pan-histone deacetylase (HDAC) inhibitors often have some toxic side effects. In this study, three series of novel polysubstituted N-alkyl acridone analogous were designed and synthesised as HDAC isoform-selective inhibitors. Among them, 11b and 11c exhibited selective inhibition of HDAC1, HDAC3, an...