Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

• Main Authors: Ze Wang (Author), Li Zhao (Author), Bo Zhang (Author), Jiahe Feng (Author), Yule Wang (Author), Bin Zhang (Author), Haixiao Jin (Author), Lijian Ding (Author), Ning Wang (Author), Shan He (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pan-histone deacetylase (HDAC) inhibitors often have some toxic side effects. In this study, three series of novel polysubstituted N-alkyl acridone analogous were designed and synthesised as HDAC isoform-selective inhibitors. Among them, 11b and 11c exhibited selective inhibition of HDAC1, HDAC3, an...