Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy

• Egile Nagusiak: Ze Wang (Egilea), Li Zhao (Egilea), Bo Zhang (Egilea), Jiahe Feng (Egilea), Yule Wang (Egilea), Bin Zhang (Egilea), Haixiao Jin (Egilea), Lijian Ding (Egilea), Ning Wang (Egilea), Shan He (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Pan-histone deacetylase (HDAC) inhibitors often have some toxic side effects. In this study, three series of novel polysubstituted N-alkyl acridone analogous were designed and synthesised as HDAC isoform-selective inhibitors. Among them, 11b and 11c exhibited selective inhibition of HDAC1, HDAC3, an...