Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy

• Main Authors: Wei Wu (Author), Wei Hu (Author), Wen-Bei Han (Author), Ying-Lu Liu (Author), Yue Tu (Author), Hai-Ming Yang (Author), Qi-Jun Fang (Author), Mo-Yi Zhou (Author), Zi-Yue Wan (Author), Ren-Mao Tang (Author), Hai-Tao Tang (Author), Yi-Gang Wan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Huangkui capsule (HKC), a Chinese modern patent medicine extracted from Abelmoschus manihot (L.) medic, has been widely applied to clinical therapy in the early diabetic nephropathy (DN) patients. However, it remains elusive whether HKC can ameliorate the inchoate glomerular injuries in hyperglycemi...