A T cell redirection platform for co-targeting dual antigens on solid tumors

• Main Authors: Leonie Enderle (Author), Karim H. Shalaby (Author), Maryna Gorelik (Author), Alexander Weiss (Author), Levi L. Blazer (Author), Marcin Paduch (Author), Lia Cardarelli (Author), Anthony Kossiakoff (Author), Jarrett J. Adams (Author), Sachdev S. Sidhu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named Dual Antigen T cell Engager (DATE), by fusing a single-chain variable fragment targeting CD3 to a tumor-targeting antigen-binding fragment. In this format, multiple novel paratope...