Single-cell sequencing analysis reveals development and differentiation trajectory of Schwann cells manipulated by M. leprae.

• Main Authors: Shanshan Ma (Author), Zihao Mi (Author), Zhenzhen Wang (Author), Lele Sun (Author), Tingting Liu (Author), Peidian Shi (Author), Chuan Wang (Author), Xiaotong Xue (Author), Wenjie Chen (Author), Zhe Wang (Author), Yueqian Yu (Author), Yuan Zhang (Author), Fangfang Bao (Author), Na Wang (Author), Honglei Wang (Author), Qianqian Xia (Author), Hong Liu (Author), Yonghu Sun (Author), Furen Zhang (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>M. leprae preferentially infects Schwann cells (SCs) in the peripheral nerves leading to nerve damage and irreversible disability. Knowledge of how M. leprae infects and interacts with host SCs is essential for understanding mechanisms of nerve damage and revealing pot...