How does re-classification of variants of unknown significance (VUS) impact the management of patients at risk for hereditary breast cancer?

• मुख्य लेखकों: Ava Kwong (लेखक), Cecilia Yuen Sze Ho (लेखक), Vivian Yvonne Shin (लेखक), Chun Hang Au (लेखक), Tsun-Leung Chan (लेखक), Edmond Shiu Kwan Ma (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2022-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background The popularity of multigene testing increases the probability of identifying variants of uncertain significance (VUS). While accurate variant interpretation enables clinicians to be better informed of the genetic risk of their patients, currently, there is a lack of consensus man...