Synthesis and cytotoxicity of apoptosis-inducing N-heterocyclic triterpene amides

• Main Authors: Benjamin Brandes (Author), Sophie Hoenke (Author), Niclas Starke (Author), Immo Serbian (Author), Hans-Peter Deigner (Author), Ahmed Al-Harrasi (Author), René Csuk (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The modification of lipophilic triterpenes to enhance their cytotoxicity, is a viable strategy for finding new anti-cancer agents. Herein we report the synthesis, analysis of 18 pentacyclic triterpenoic acid N-heterocyclic amides and their cytotoxicity, tumor cell/non-tumor cell selectivity, as well...