LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania.

• Principais autores: Jenny Campos-Salinas (Autor), David León-Guerrero (Autor), Elena González-Rey (Autor), Mario Delgado (Autor), Santiago Castanys (Autor), José M Pérez-Victoria (Autor), Francisco Gamarro (Autor)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Leishmaniasis is a neglected disease produced by the intracellular protozoan parasite Leishmania. In the present study, we show that LABCG2, a new ATP-binding cassette half-transporter (ABCG subfamily) from Leishmania, is involved in parasite virulence. Down-regulation of LABCG2 function upon expres...