Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells

• প্রধান লেখক: Zeynep Özdemir (লেখক), Semra Utku (লেখক), Bijo Mathew (লেখক), Simone Carradori (লেখক), Giustino Orlando (লেখক), Simonetta Di Simone (লেখক), Mehmet Abdullah Alagöz (লেখক), Azime Berna Özçelik (লেখক), Mehtap Uysal (লেখক), Claudio Ferrante (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Novel 3(2H)-pyridazinone derivatives were designed, synthesised in satisfactory yields and evaluated in different experimental assays to assess their preliminary toxicity in vivo and anti-proliferative effects against HCT116 cell lines in vitro. Artemia salina lethality test provided LC50 values >...