Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells

• Main Authors: Zeynep Özdemir (Author), Semra Utku (Author), Bijo Mathew (Author), Simone Carradori (Author), Giustino Orlando (Author), Simonetta Di Simone (Author), Mehmet Abdullah Alagöz (Author), Azime Berna Özçelik (Author), Mehtap Uysal (Author), Claudio Ferrante (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel 3(2H)-pyridazinone derivatives were designed, synthesised in satisfactory yields and evaluated in different experimental assays to assess their preliminary toxicity in vivo and anti-proliferative effects against HCT116 cell lines in vitro. Artemia salina lethality test provided LC50 values >...