Ketamine promptly normalizes excess norepinephrine and enhances dopamine neuronal activity in Wistar Kyoto rats

• Glavni autori: Stephen Daniels (Autor), Mostafa El Mansari (Autor), Rami Hamoudeh (Autor), Pierre Blier (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Ketamine acts primarily by blocking the N-methyl-D-aspartate (NMDA) receptor at the phencyclidine site. The rapid antidepressant properties of ketamine were demonstrated in the clinic and several behavioral models of depression in rodents. We hypothesized that the normalization of abnormal activity...