Secondary follicles enable efficient germline mtDNA base editing at hard-to-edit site

• Main Authors: Qin Xie (Author), Haibo Wu (Author), Hui Long (Author), Caiwen Xiao (Author), Jiaxin Qiu (Author), Weina Yu (Author), Xueyi Jiang (Author), Junbo Liu (Author), Shuo Zhang (Author), Qifeng Lyu (Author), Lun Suo (Author), Yanping Kuang (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Efficient germline mtDNA editing is required to construct disease-related animal models and future gene therapy. Recently, the DddA-derived cytosine base editors (DdCBEs) have made mitochondrial genome (mtDNA) precise editing possible. However, there still exist challenges for editing some mtDNA sit...