Mitochondria Targeted Antioxidant Significantly Alleviates Preeclampsia Caused by 11β-HSD2 Dysfunction via OPA1 and MtDNA Maintenance

• Main Authors: Jing Long (Author), Yan Huang (Author), Zhengshan Tang (Author), Yali Shan (Author), Dou Feng (Author), Wenqin Wang (Author), Juan Liu (Author), Ying Huang (Author), Hang Gu (Author), Dewei Guo (Author), Ruojin Yao (Author), Xin Ni (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2022-07-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

We have previously demonstrated that placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) dysfunction contributes to PE pathogenesis. We sought to elucidate molecular mechanisms underlying 11β-HSD2 dysfunction-induced PE and to seek potential therapeutic targets using a 11β-HSD2 dysfunction-...