The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases

• Main Authors: Susana S. Correia (Author), Rajesh R. Iyengar (Author), Peter Germano (Author), Kim Tang (Author), Sylvie G. Bernier (Author), Chad D. Schwartzkopf (Author), Jenny Tobin (Author), Thomas W.-H. Lee (Author), Guang Liu (Author), Sarah Jacobson (Author), Andrew Carvalho (Author), Glen R. Rennie (Author), Joon Jung (Author), Paul A. Renhowe (Author), Elisabeth Lonie (Author), Christopher J. Winrow (Author), John R. Hadcock (Author), Juli E. Jones (Author), Mark G. Currie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that binds to soluble guanylate cyclase (sGC) to produce cyclic guanosine monophosphate...