Selective inhibition of carbonic anhydrase-IX by sulphonamide derivatives induces pH and reactive oxygen species-mediated apoptosis in cervical cancer HeLa cells

• Päätekijät: Ismail Koyuncu (Tekijä), Ataman Gonel (Tekijä), Abdurrahim Kocyigit (Tekijä), Ebru Temiz (Tekijä), Mustafa Durgun (Tekijä), Claudiu T. Supuran (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Selective inhibition with sulphonamides of carbonic anhydrase (CA) IX reduces cell proliferation and induces apoptosis in human cancer cells. The effect on CA IX expression of seven previously synthesised sulphonamide inhibitors, with high affinity for CA IX, as well as their effect on the prolifera...