Single-Cell Transcriptomic and Targeted Genomic Profiling Adjusted for Inflammation and Therapy Bias Reveal <i>CRTAM</i> and <i>PLCB1</i> as Novel Hub Genes for Anti-Tumor Necrosis Factor Alpha Therapy Response in Crohn's Disease

Single-Cell Transcriptomic and Targeted Genomic Profiling Adjusted for Inflammation and Therapy Bias Reveal <i>CRTAM</i> and <i>PLCB1</i> as Novel Hub Genes for Anti-Tumor Necrosis Factor Alpha Therapy Response in Crohn's Disease

Background: The lack of reliable biomarkers in response to anti-TNFα biologicals hinders personalized therapy for Crohn's disease (CD) patients. The motivation behind our study is to shift the paradigm of anti-TNFα biomarker discovery toward specific immune cell sub-populations using single-cel...

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Main Authors: Mario Gorenjak (Author), Boris Gole (Author), Larisa Goričan (Author), Gregor Jezernik (Author), Uršula Prosenc Zmrzljak (Author), Cvetka Pernat (Author), Pavel Skok (Author), Uroš Potočnik (Author)
Format: Book
Published: MDPI AG, 2024-06-01T00:00:00Z.
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