Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in healthy volunteers

• Main Authors: Vishal Goyal (Author), Edrich Krantz (Author), Francois Simon (Author), Anouk Neven (Author), Johanna Eriksson (Author), Amaria Saayman (Author), Nabila Ibnou Zekri Lassout (Author), Mathieu Louis (Author), Stephen Robinson (Author), Abhijit Deshmukh (Author), Amit Antarkar (Author), Carol Ruffell (Author), Sarika Victor (Author), Marylore Chenel (Author), Aljosa Celebic (Author), Henri Caplain (Author), Jean‐Yves Gillon (Author), Isabela Ribeiro (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The opportunistic fungal infection cryptococcal meningoencephalitis is a major cause of death among people living with HIV in sub‐Saharan Africa. We report pharmacokinetic (PK) and safety data from a randomized, four‐period crossover phase I trial of three sustained‐release (SR) oral pellet...