Cross-Validation of a Multiplex LC-MS/MS Method for Assaying mAbs Plasma Levels in Patients with Cancer: A GPCO-UNICANCER Study

• Main Authors: Clémence Marin (Author), Nihel Khoudour (Author), Aurélien Millet (Author), Dorothée Lebert (Author), Pauline Bros (Author), Fabienne Thomas (Author), David Ternant (Author), Bruno Lacarelle (Author), Jérôme Guitton (Author), Joseph Ciccolini (Author), Benoit Blanchet (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Different liquid chromatography tandem mass spectrometry (LC-MS/MS) methods have been published for quantification of monoclonal antibodies (mAbs) in plasma but thus far none allowed the simultaneous quantification of several mAbs, including immune checkpoint inhibitors. We developed and...