Kynureninase Promotes Immunosuppression and Predicts Survival in Glioma Patients: In Silico Data Analyses of the Chinese Glioma Genome Atlas (CGGA) and of the Cancer Genome Atlas (TCGA)

• Principais autores: Gonzalo Pérez de la Cruz (Autor), Verónica Pérez de la Cruz (Autor), Javier Navarro Cossio (Autor), Gustavo Ignacio Vázquez Cervantes (Autor), Aleli Salazar (Autor), Mario Orozco Morales (Autor), Benjamin Pineda (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2023-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Kynureninase (KYNU) is a kynurenine pathway (KP) enzyme that produces metabolites with immunomodulatory properties. In recent years, overactivation of KP has been associated with poor prognosis of several types of cancer, in particular by promoting the invasion, metastasis, and chemoresistance of ca...