mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis

• Main Authors: Manami Hiraiwa (Author), Kakeru Ozaki (Author), Takanori Yamada (Author), Takashi Iezaki (Author), Gyujin Park (Author), Kazuya Fukasawa (Author), Tetsuhiro Horie (Author), Hikari Kamada (Author), Kazuya Tokumura (Author), Mei Motono (Author), Katsuyuki Kaneda (Author), Eiichi Hinoi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mechanistic/mammalian target of rapamycin (mTOR) is widely implicated in the pathogenesis of various diseases, including cancer, obesity, and cardiovascular disease. Bone homeostasis is maintained by the actions of bone-resorbing osteoclasts and bone-forming osteoblasts. An imbalance in the soph...