Protective Effect of α-Lipoic Acid Against Arsenic Trioxide-Induced Acute Cardiac Toxicity in Rats

• Main Authors: Masafumi Kumazaki (Author), Hitoshi Ando (Author), Akira Sasaki (Author), Taka-aki Koshimizu (Author), Kentarou Ushijima (Author), Keiko Hosohata (Author), Yasuo Oshima (Author), Akio Fujimura (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical use of arsenic trioxide (ATO) is often limited because of its adverse effects. We examined whether α-lipoic acid (LA) protects against the ATO-induced cardiac toxicity. In the chronic study, two of four rats suddenly died by the repeated dosing of ATO, whereas no deaths were observed in...