Synergistic antitumor activity of baicalein combined with almonertinib in almonertinib-resistant non-small cell lung cancer cells through the reactive oxygen species-mediated PI3K/Akt pathway

• Autors principals: Teng Chen (Autor), Pei Zhang (Autor), Xiao-Fan Cong (Autor), Yuan-Yuan Wang (Autor), Shuo Li (Autor), Hao Wang (Autor), Su-Rong Zhao (Autor), Xiao-Jin Sun (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

IntroductionAlmonertinib is an important third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) exhibiting high selectivity to EGFR-sensitizing and T790M-resistant mutations. Almonertinib resistance is a major obstacle in clinical use. Baicalein possesses antitumor pr...