Analysis of the TSER and G>C variants in the TYMS gene: a high frequency of low expression genotypes predicted in the Mexican population

• Main Authors: Alma Faviola Favela-Mendoza (Author), Andrea Dinorah Godínez-López (Author), Mariana Chávez-Arreguin (Author), José Alonso Aguilar-Velázquez (Author), Gabriela Martínez-Cortes (Author), Héctor Rangel-Villalobos (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background In the TYMS gene promoter, there is a repeat polymorphism (TSER) that affects the expression level of the thymidylate synthetase (TS) enzyme involved in the response to some anticancer drugs. The G>C transversion located in the TSER*3R allele decreases the expression level of the TS en...