Association of MTHFD1 gene polymorphisms and maternal smoking with risk of congenital heart disease: a hospital-based case-control study

• Main Authors: Xinli Song (Author), Qiongxuan Li (Author), Jingyi Diao (Author), Jinqi Li (Author), Yihuan Li (Author), Senmao Zhang (Author), Lijuan Zhao (Author), Letao Chen (Author), Jianhui Wei (Author), Jing Shu (Author), Yiping Liu (Author), Mengting Sun (Author), Peng Huang (Author), Tingting Wang (Author), Jiabi Qin (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background MTHFD1 gene may affect the embryonic development by elevated homocysteine levels, DNA synthesis and DNA methylation, but limited number of genetic variants of MTHFD1 gene was focused on the association with congenital heart disease (CHD). This study examined the role of MTHFD1 ge...