Promises and pitfalls of a Pannexin1 transgenic mouse line.

• Main Authors: Regina eHanstein (Author), Hiromitsu eNegoro (Author), Naman K. Patel (Author), Anne eCharollais (Author), Paolo eMeda (Author), David C. Spray (Author), Sylvia O. Suadicani (Author), Eliana eScemes (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a knockout at the RNA processing level and also allows for the generation of conditional KO alleles by combining FLP/FRT and Cre/loxP syst...