Great Increase in Antinociceptive Potency of [Leu5]Enkephalin After Peptidase Inhibition

• Egile Nagusiak: Kazuhito Akahori (Egilea), Kenya Kosaka (Egilea), Xing Lu Jin (Egilea), Yoshiharu Arai (Egilea), Masanobu Yoshikawa (Egilea), Hiroyuki Kobayashi (Egilea), Tetsuo Oka (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2008-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Previous in vitro studies have shown that the degradation of [Leu5]enkephalin during incubation with cerebral membrane preparations is almost completely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon. The present in vivo study shows that the inhibitory...