Great Increase in Antinociceptive Potency of [Leu5]Enkephalin After Peptidase Inhibition

• Main Authors: Kazuhito Akahori (Author), Kenya Kosaka (Author), Xing Lu Jin (Author), Yoshiharu Arai (Author), Masanobu Yoshikawa (Author), Hiroyuki Kobayashi (Author), Tetsuo Oka (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous in vitro studies have shown that the degradation of [Leu5]enkephalin during incubation with cerebral membrane preparations is almost completely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon. The present in vivo study shows that the inhibitory...