A Biophysical Insight of Camptothecin Biodistribution: Towards a Molecular Understanding of Its Pharmacokinetic Issues

• Auteurs principaux: Andreia Almeida (Auteur), Eduarda Fernandes (Auteur), Bruno Sarmento (Auteur), Marlene Lúcio (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-06-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Camptothecin (CPT) is a potent anticancer drug, and its putative oral administration is envisioned although difficult due to physiological barriers that must be overcome. A comprehensive biophysical analysis of CPT interaction with biointerface models can be used to predict some pharmacokinetic issu...