A Biophysical Insight of Camptothecin Biodistribution: Towards a Molecular Understanding of Its Pharmacokinetic Issues

• Main Authors: Andreia Almeida (Author), Eduarda Fernandes (Author), Bruno Sarmento (Author), Marlene Lúcio (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2021-06-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Camptothecin (CPT) is a potent anticancer drug, and its putative oral administration is envisioned although difficult due to physiological barriers that must be overcome. A comprehensive biophysical analysis of CPT interaction with biointerface models can be used to predict some pharmacokinetic issu...