Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3β

• Main Authors: Yingui Li (Author), Yijing Zhao (Author), Xiaoqin Tan (Author), Jiayan Liu (Author), Yingkun Zhi (Author), Lang Yi (Author), Shasha Bai (Author), Qun Du (Author), Qing X. Li (Author), Yan Dong (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isoorientin has anti-inflammatory effects; however, the mechanism remains unclear. We previously found isoorientin is an inhibitor of glycogen synthase kinase 3β (GSK3β) in vitro. Overactivation of GSK3β is associated with inflammatory responses. GSK3β is inactivated by phosphorylation at Ser9 (i.e....