Immune escape of multiple myeloma cells results from low miR29b and the ensuing epigenetic silencing of proteasome genes

• Main Authors: Patrizia Leone (Author), Eleonora Malerba (Author), Marcella Prete (Author), Antonio Giovanni Solimando (Author), Giorgio Alberto Croci (Author), Paolo Ditonno (Author), Marco Tucci (Author), Nicola Susca (Author), Afshin Derakhshani (Author), Antoine Dufour (Author), Valli De Re (Author), Nicola Silvestris (Author), Vito Racanelli (Author)
• Format: Book
• Published: BMC, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Activation of CD28 on multiple myeloma (MM) plasma cells, by binding to CD80 and CD86 on dendritic cells, decreases proteasome subunit expression in the tumor cells and thereby helps them evade being killed by CD8+ T cells. Understanding how CD28 activation leads to proteasome su...