Chitooligosaccharides Improve the Efficacy of Checkpoint Inhibitors in a Mouse Model of Lung Cancer

• Main Authors: Astrid Zedlitz Johansen (Author), Marco Carretta (Author), Marie-Louise Thorseth (Author), Shawez Khan (Author), Klaire Yixin Fjæstad (Author), Christian Beltoft Brøchner (Author), Hannes Linder (Author), Christina Ankjærgaard (Author), Marco Donia (Author), Inna Chen (Author), Dorte Lisbet Nielsen (Author), Claus Preibisch Behrens (Author), Daniel Hargbøl Madsen (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

YKL-40 (also named chitinase 3 like-1 protein [CHI3L1]) is a secreted chitinase-like protein which is upregulated in cancers and suggested to have pro-tumorigenic activity. YKL-40 lacks enzymatic function, but it can bind carbohydrates such as chitin. Chitooligosaccharides (COS) derived from deacety...