Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate-induced colitis in mice lacking microsomal prostaglandin E synthase-1

• Main Authors: Fumiaki Kojima (Author), Hiroki Sekiya (Author), Yuka Hioki (Author), Hitoshi Kashiwagi (Author), Makoto Kubo (Author), Masaki Nakamura (Author), Shotaro Maehana (Author), Yoshitaka Imamichi (Author), Koh-ichi Yuhki (Author), Fumitaka Ushikubi (Author), Hidero Kitasato (Author), Takafumi Ichikawa (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H2 to PGE2. The present study investigated the effect of genetic deletion of mPGES-1 on the development o...