Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats

• Principais autores: Won Seok Bang (Autor), Ye Ran Hwang (Autor), Zhengri Li (Autor), Inchul Lee (Autor), Hee Eun Kang (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Purpose: Preliminary study results have shown that rats with non-alcoholic fatty liver disease (NAFLD) induced by 1% orotic acid-containing diet have decreased hepatic CYP2D activity. This study aims to evaluate the possible pharmacokinetic changes in NAFLD as a result of reduced metabolic activity...