Bottom-Up Physiologically Based Oral Absorption Modeling of Free Weak Base Drugs

• Những tác giả chính: Naoya Matsumura (Tác giả), Asami Ono (Tác giả), Yoshiyuki Akiyama (Tác giả), Takuya Fujita (Tác giả), Kiyohiko Sugano (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2020-09-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

In this study, we systematically evaluated "bottom-up" physiologically based oral absorption modeling, focusing on free weak base drugs. The gastrointestinal unified theoretical framework (the GUT framework) was employed as a simple and transparent model. The oral absorption of poorly solu...