Bottom-Up Physiologically Based Oral Absorption Modeling of Free Weak Base Drugs

In this study, we systematically evaluated "bottom-up" physiologically based oral absorption modeling, focusing on free weak base drugs. The gastrointestinal unified theoretical framework (the GUT framework) was employed as a simple and transparent model. The oral absorption of poorly solu...

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Autores principales: Naoya Matsumura (Autor), Asami Ono (Autor), Yoshiyuki Akiyama (Autor), Takuya Fujita (Autor), Kiyohiko Sugano (Autor)
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Publicado: MDPI AG, 2020-09-01T00:00:00Z.
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