Advancing drug safety and mitigating health concerns: High-resolution mass spectrometry in the levothyroxine case study

• Main Authors: Hana Chmelařová (Author), Maria Carmen Catapano (Author), Jean-Christophe Garrigues (Author), František Švec (Author), Lucie Nováková (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Levothyroxine is a drug with a narrow therapeutic index. Changing the drug formulation composition or switching between pharmaceutical brands can alter the bioavailability, which can result in major health problems. However, the increased adverse drug reactions have not been fully explained scientif...