Experimental and Computational Investigation of the Oxime Bond Stereochemistry in c-Jun N-terminal Kinase 3 Inhibitors 11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-one Oxime and Tryptanthrin-6-oxime

• Main Authors: Vladislava V. Matveevskaya (Author), Dmitry I. Pavlov (Author), Anastasia R. Kovrizhina (Author), Taisiya S. Sukhikh (Author), Evgeniy H. Sadykov (Author), Pavel V. Dorovatovskii (Author), Vladimir A. Lazarenko (Author), Andrei I. Khlebnikov (Author), Andrei S. Potapov (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

11<i>H</i>-Indeno[1,2-<i>b</i>]quinoxalin-11-one oxime (<b>IQ-1</b>) and tryptanthrin-6-oxime are potent c-Jun N-terminal kinase 3 (JNK-3) inhibitors demonstrating neuroprotective, anti-inflammatory and anti-arthritic activity. However, the stereochemical configur...