Pulsatile Bi-Directional Aerosol Flow Affects Aerosol Delivery to the Intranasal Olfactory Region: A Patient-Specific Computational Study

• Главные авторы: Ali Farnoud (Автор), Hesam Tofighian (Автор), Ingo Baumann (Автор), Andrew R. Martin (Автор), Mohammad M. Rashidi (Автор), Micheal P. Menden (Автор), Otmar Schmid (Автор)
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• Опубликовано: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Предметы: article
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The nasal olfactory region is a potential route for non-invasive delivery of drugs directly from the nasal epithelium to the brain, bypassing the often impermeable blood-brain barrier. However, efficient aerosol delivery to the olfactory region is challenging due to its location in the nose. Here we...