Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies

• Egile Nagusiak: Huseyin Cavdar (Egilea), Murat Senturk (Egilea), Murat Guney (Egilea), Serdar Durdagi (Egilea), Gulru Kayik (Egilea), Claudiu T. Supuran (Egilea), Deniz Ekinci (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are interesting compounds for different therapeutic applications, among which Alzheimer's disease. Here, we investigated the inhibition of these cholinesterases with uracil derivatives. The mechanism of inhibition of these...