Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways

• Main Authors: Minjie Zhang (Author), Jiaxi Qu (Author), Zhiwei Gao (Author), Qi Qi (Author), Hong Yin (Author), Ling Zhu (Author), Yichen Wu (Author), Wei Liu (Author), Jian Yang (Author), Xuefeng Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Timosaponin AIII (TAIII), a steroidal saponin, exerts potent anti-tumor activity in various cancers, especially breast cancer. However, the concrete molecular mechanisms of TAIII against breast cancer are still unclear. Here, we find that TAIII triggers DNA damage, leads to G2/M arrest, and ultimate...