Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways

• Автори: Minjie Zhang (Автор), Jiaxi Qu (Автор), Zhiwei Gao (Автор), Qi Qi (Автор), Hong Yin (Автор), Ling Zhu (Автор), Yichen Wu (Автор), Wei Liu (Автор), Jian Yang (Автор), Xuefeng Huang (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Timosaponin AIII (TAIII), a steroidal saponin, exerts potent anti-tumor activity in various cancers, especially breast cancer. However, the concrete molecular mechanisms of TAIII against breast cancer are still unclear. Here, we find that TAIII triggers DNA damage, leads to G2/M arrest, and ultimate...