IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy

• Main Authors: Mehboob Ali (Author), Mehak Gupta (Author), Abubakar Wani (Author), Ankita Sharma (Author), Mohd Abdullaha (Author), Dilpreet Kour (Author), Sushil Choudhary (Author), Sandip B. Bharate (Author), Gurdarshan Singh (Author), Ajay Kumar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant activation of NLRP3 inflammasome has been implicated in several inflammatory diseases. Autophagy is one of the primary mechanisms that regulate NLRP3 inflammasome activity. In this study, we attempted to target NLRP3 inflammasome activity by a synthetic compound IIIM-941. We found that IIIM...