Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy

• Main Authors: Bruno Solano de Freitas Souza (Author), Kátia Nunes da Silva (Author), Daniela Nascimento Silva (Author), Vinícius Pinto Costa Rocha (Author), Bruno Diaz Paredes (Author), Carine Machado Azevedo (Author), Carolina Kymie Nonaka (Author), Gisele Batista Carvalho (Author), Juliana Fraga Vasconcelos (Author), Ricardo Ribeiro dos Santos (Author), Milena Botelho Pereira Soares (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with Trypanosoma cruzi, the exacerbated immune response plays a critical pathophysiological rol...