theLiTE™: A Screening Platform to Identify Compounds that Reinforce Tight Junctions

• Hauptverfasser: Teresa Lopes Gomes (Verfasst von), Virgínia de Oliveira-Marques (Verfasst von), Richard John Hampson (Verfasst von), António Jacinto (Verfasst von), Luciana Vieira de Moraes (Verfasst von), Rui Gonçalo Martinho (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Tight junctions (TJ) are formed by transmembrane and intracellular proteins that seal the intercellular space and control selective permeability of epithelia. Integrity of the epithelial barrier is central to tissue homeostasis and barrier dysfunction has been linked to many pathological conditions....