Pharmacological characterization of a novel potent, selective, and orally active orexin 2 receptor antagonist, SDM‐878

Abstract Aims Recently, we identified a novel orexin 2 (OX2) receptor antagonist, SDM‐878 (2‐(3‐(2‐(1H‐pyrazol‐1‐yl)nicotinoyl)‐3,8‐diazabicyclo[3.2.1]octan‐8‐yl)‐3‐methoxyisonicotinonitrile). The purpose of the present study is to characterize the in vitro and in vivo pharmacological effects of SDM...

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Main Authors: Shunsuke Maehara (Author), Natsuko Yuge (Author), Chika Higashi (Author), Takumi Ota (Author), Junji Furukawa (Author), Takashi Takeuchi (Author)
Format: Book
Published: Wiley, 2020-06-01T00:00:00Z.
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