Pharmacological characterization of a novel potent, selective, and orally active orexin 2 receptor antagonist, SDM‐878

• Glavni autori: Shunsuke Maehara (Autor), Natsuko Yuge (Autor), Chika Higashi (Autor), Takumi Ota (Autor), Junji Furukawa (Autor), Takashi Takeuchi (Autor)
• Format: Knjiga
• Izdano: Wiley, 2020-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Aims Recently, we identified a novel orexin 2 (OX2) receptor antagonist, SDM‐878 (2‐(3‐(2‐(1H‐pyrazol‐1‐yl)nicotinoyl)‐3,8‐diazabicyclo[3.2.1]octan‐8‐yl)‐3‐methoxyisonicotinonitrile). The purpose of the present study is to characterize the in vitro and in vivo pharmacological effects of SDM...