Pharmacological characterization of a novel potent, selective, and orally active orexin 2 receptor antagonist, SDM‐878

• Asıl Yazarlar: Shunsuke Maehara (Yazar), Natsuko Yuge (Yazar), Chika Higashi (Yazar), Takumi Ota (Yazar), Junji Furukawa (Yazar), Takashi Takeuchi (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2020-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Aims Recently, we identified a novel orexin 2 (OX2) receptor antagonist, SDM‐878 (2‐(3‐(2‐(1H‐pyrazol‐1‐yl)nicotinoyl)‐3,8‐diazabicyclo[3.2.1]octan‐8‐yl)‐3‐methoxyisonicotinonitrile). The purpose of the present study is to characterize the in vitro and in vivo pharmacological effects of SDM...