Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro

• Main Authors: Amy H. Lin (Author), Christopher G. Twitty (Author), Ryan Burnett (Author), Andrew Hofacre (Author), Leah A. Mitchell (Author), Fernando Lopez Espinoza (Author), Harry E. Gruber (Author), Douglas J. Jolly (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor cells express a number of immunosuppressive molecules that can suppress anti-tumor immune responses. Efficient delivery of small interfering RNAs to treat a wide range of diseases including cancers remains a challenge. Retroviral replicating vectors (RRV) can be used to stably and selectively...