Discovery of Novel Doxorubicin Metabolites in MCF7 Doxorubicin-Resistant Cells

• Main Authors: Xu Wang (Author), Renjie Hui (Author), Yun Chen (Author), Wentao Wang (Author), Yujiao Chen (Author), Xiaohai Gong (Author), Jian Jin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin (DOX) is metabolized to a variety of metabolites in vivo, which has been shown to be associated with cardiotoxicity. We speculate that metabolic processes are also present in tumor cells. A LC-MS/MS method was developed to detect intracellular metabolites. Drug resistant tumor cells with...