Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration

• Main Authors: Beatrice Severino (Author), Angela Corvino (Author), Ferdinando Fiorino (Author), Francesco Frecentese (Author), Elisa Perissutti (Author), Giuseppe Caliendo (Author), Vincenzo Santagada (Author), Elisa Magli (Author), Pasquale Molinaro (Author), Giuseppe Pignataro (Author), Lucio Annunziato (Author), Natalícia J. Antunes (Author), Julio Rojas-Moscoso (Author), Noedi L. de Freitas (Author), Gustavo D. Mendes (Author), Gilberto De Nucci (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neurounina-1 [chemical name: 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one] is a new compound provided with relevant neuroprotective effect during stroke and in neonatal hypoxia by increasing the Na+/Ca2+ exchanger (NCX) isoforms NCX1 and NCX2 activity. This study sho...