Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment

• Main Authors: Yong Li (Author), Dongmei Zhang (Author), Jun Xu (Author), Junmin Shi (Author), Lei Jiang (Author), Nan Yao (Author), Wencai Ye (Author)
• Format: Book
• Published: Elsevier, 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that plays a vital role in the signal transduction of cancers. Hsp90 inhibitors are able to inhibit Hsp90 or the complex of Hsp90 and co-chaperones resulting in the degradation of Hsp90-dependent client proteins through the ubiq...